The Yamato ONC-362DS001 is the On-chip Droplet Selector HS, a microfluidic instrument that identifies, sorts, and dispenses specific water-in-oil (W/O) droplets containing cells or microorganisms. It enables high-throughput, damage-free screening of encapsulated samples and dispenses individual selected droplets directly into 96- or 384-well plates, one droplet at a time. This HS configuration is equipped with 488 nm, 638 nm, and 405 nm excitation lasers for multiplexed fluorescence detection during sorting.
Key Specifications
| SKU | ONC-362DS001 |
| Product | On-chip Droplet Selector HS |
| Detection lasers | 488 nm, 638 nm, 405 nm |
| Sample format | Water-in-oil (W/O) droplets encapsulating cells or microorganisms |
| Function | Identify, sort, and dispense selected droplets |
| Dispensing | Direct into 96- or 384-well plates, one droplet at a time |
| Handling | High-throughput, damage-free (gentle) screening |
| List price | Contact for pricing (TBA) |
Application Profile
Droplet microfluidics has become a backbone of single-cell and single-microorganism screening because each droplet is an isolated picoliter reactor — one cell, its secretions, and an assay, walled off from every neighbor. The bottleneck has always been getting the *right* droplet *out* without destroying it or its contents. The On-chip Droplet Selector solves that: it reads each droplet's fluorescence on the fly, decides whether it matches the target, and dispenses the winners into a defined well.
The damage-free dispensing is the differentiator — cells or microorganisms in a selected droplet arrive in the destination well intact and viable, ready for clonal expansion, sequencing, or downstream culture. Because droplets go one at a time into addressable 96- or 384-well plates, the workflow supports clean single-cell isolation, antibody-discovery screens, directed-evolution selections, and rare-variant enrichment. The 488/638/405 nm laser set on this HS variant covers common fluorophores excited in the blue, red, and violet ranges for multiparameter gating.
Frequently Asked Questions
What does the On-chip Droplet Selector do? It identifies, sorts, and dispenses specific water-in-oil (W/O) droplets containing cells or microorganisms, placing selected droplets directly into well plates.
Which lasers does this HS model have? The HS (ONC-362DS001) is equipped with 488 nm, 638 nm, and 405 nm excitation lasers.
Where are the sorted droplets dispensed? Directly into 96- or 384-well plates, one droplet at a time, so each well receives a defined, selected droplet.
Is the sorting gentle on cells? Yes — it performs damage-free dispensing, so encapsulated cells or microorganisms remain intact for downstream culture, sequencing, or analysis.
What applications is it used for? High-throughput single-cell and single-microorganism screening — clonal isolation, antibody discovery, directed evolution, and rare-cell enrichment.
How do the HS, HSG, and HSGR versions differ? Only by their laser configuration. HS uses 488/638/405 nm; HSG (ONC-362DS001G) uses 488/561/405 nm; HSGR (ONC-362DS001GR) uses 488/638/561 nm — choose the set that matches your fluorophores.
Ordering & Configuration
Confirm at quote: your fluorophore panel (to select HS vs HSG vs HSGR), target plate format (96 vs 384), and chip/consumable supply.
Warranty: Per Yamato standard capital-equipment terms — confirm coverage at quote.
Add to a quote to request current pricing and lock configuration and lead time.
On-chip Droplet Selector variants (laser set is the only difference):
- HS — ONC-362DS001 (this product) — 488 / 638 / 405 nm
- HSG — ONC-362DS001G — 488 / 561 / 405 nm
- HSGR — ONC-362DS001GR — 488 / 638 / 561 nm
Pick the variant whose excitation lines match your reporters; the sorting, dispensing, and damage-free handling are identical across all three.
