The IsoPure™ 24 is Accuris's mid-throughput automated magnetic-bead purification platform — a $51,618 institutional-procurement instrument that processes up to 24 samples in a single hands-off run, isolating DNA, RNA, or protein from biological samples using whichever magnetic-bead reagent kit fits the workflow. The IsoPure 24 sits between the smaller IsoPure Mini (16-sample throughput, $11K, AP1016) and the high-throughput IsoPure 96 (96-sample deep-well, $49K, AP1096). It's compatible with all popular magnetic-bead kits, so the workflow choice (Qiagen, Promega, NEB, Thermo, Zymo, or any third-party magnetic-bead chemistry) doesn't lock the lab into a proprietary reagent stream.
Voltage options: This unit can be ordered with European voltage requirements (230V/50Hz). Contact us to order.
Key Specifications
| Capacity / sample volume | 24 samples per run / 50 µL to 10,000 µL per sample |
| Plate positions | 8 positions on the carousel |
| Carousel layout | 8-position with 2 heating blocks for lysis and elution temperature control |
| Lysis temperature range | Ambient +5 °C to 120 °C |
| Elution temperature range | Ambient +5 °C to 120 °C |
| Mixing speed | Variable, 10 levels |
| Display | 7.0-inch color touchscreen |
| Programming | Touchscreen / mouse on instrument; PC connection supported |
| Program memory | 100 protocols stored on-instrument |
| Communication | USB, LAN, PC connection |
| Magnetic bead recovery rate | > 95 % |
| Internal lighting | LED for chamber visibility |
| Contamination control | UV sterilization with included lamp (3 W, 253.7 nm) |
| Dimensions (W × D × H) | 15.7 × 20.5 × 17.7 in (40 × 52 × 45 cm) |
| Weight | 30 kg (66.1 lb) |
| Electrical input | Universal 120 to 240 VAC |
| Warranty | 2 years (extended from typical Accuris standard) |
| List price | $51,618 |
Application Profile
Hands-off DNA / RNA / Protein extraction at mid-throughput. Where manual magnetic-bead protocols require continuous operator attention through 8–12 pipetting steps per sample, the IsoPure 24 runs the lysis → bind → wash × N → elute sequence automatically across all 24 samples. A 24-sample run typical of clinical-research, biobank, or core-facility batch workflows that's repetitive and time-consuming when run manually.
Sample-volume flexibility from microvolume to 10 mL. The 50 µL to 10,000 µL range covers everything from small biopsy samples and limited blood-spot extractions up to 10 mL stool, swab, or environmental samples — a single instrument bridging clinical-research microvolume and bulk-sample applications.
Multi-kit chemistry compatibility. "Compatible with all popular magnetic bead kits" means lab procurement isn't tied to a proprietary reagent SKU. Useful for cores serving multiple PI groups whose preferred kit chemistry differs.
Lysis and elution at controlled temperature. Two on-carousel heating blocks (ambient +5 °C to 120 °C each) handle the heated lysis steps that many protocols require for difficult-to-lyse samples (Gram-positive bacteria, plant tissue, fungal cells, archived tissue) plus controlled-temperature elution where reagent kit specifies it.
UV decontamination between runs. The included 3 W / 253.7 nm UV lamp performs surface decontamination of the chamber between runs — important for clinical workflows where cross-contamination would compromise downstream PCR / sequencing.
Multi-protocol cores. 100-protocol on-instrument memory means a shared instrument can store the standard protocols for every kit chemistry the lab uses, callable by name from the touchscreen.
Design Architecture
8-position carousel with 2 integrated heating blocks. The carousel design optimizes mechanical motion of the bead-transfer comb across the plate positions; the heating blocks sit at the lysis and elution positions in the standard plate layout. IsoPure deep-well plates fit into the heating blocks for efficient heat transfer during the temperature-controlled steps.
Magnetic-bead transfer comb. A pin-down magnetic comb (the 24-Place Magnetic Assembly + 24-Place Tip Comb consumables) collects beads from one well, transfers them to the next position, and releases them. This is the mechanical core of every magnetic-bead automation platform; the IsoPure 24's > 95 % bead-recovery spec defines the workflow's yield.
Variable mixing speed (10 levels). Mixing parameters can be programmed per protocol step — useful for methods that specify gentle vs vigorous mixing during different stages (gentle during binding to avoid bead aggregation, vigorous during washing for thorough elution).
Touchscreen with on-board programming. Protocols are created and modified directly on the 7-inch touchscreen, no PC required for routine operation. PC connection (USB / LAN) supports protocol export/import and centralized data management.
LED internal lighting for chamber visibility through the lid — useful for tracking protocol progress visually without opening the chamber mid-run.
UV decontamination lamp (3 W, 253.7 nm) — included as standard. Run between batches to reduce cross-contamination risk.
Frequently Asked Questions
How many samples can the IsoPure 24 process per run, and at what volume range? Up to 24 samples per run, at 50 µL to 10,000 µL per sample.
Which magnetic-bead kits is the IsoPure 24 compatible with? All popular magnetic-bead kits — the workflow is not locked to a proprietary reagent stream.
What is the magnetic-bead recovery rate? Greater than 95 %.
What warranty does the AP1024 carry? 2 years — extended above the typical Accuris standard, reflecting the institutional-procurement positioning of the IsoPure platform.
How does the IsoPure 24 compare to the other IsoPure systems? It sits between the IsoPure Mini (16-sample, 50–1,000 µL, $11,027) and the IsoPure 96 (96-sample deep-well, $49,376); all three accept the same magnetic-bead kit chemistries.
Ordering & Configuration
Standard configuration. The AP1024 ships with the instrument, 24-Place Magnetic Assembly, 7-inch touchscreen, UV decontamination lamp, universal 120–240 V power cord, operator's manual, and packaging materials.
Consumables (sold separately):
- AP1024-DWP — 24-deep-well plates for IsoPure 24, pack of 50
- AP1024-TC — Tip Comb for IsoPure 24, pack of 50
Voltage variants:
- AP1024 — 115 V plug (this SKU)
Family alternatives:
- AP1016 IsoPure Mini — 16-sample throughput, 50 µL to 1,000 µL volume, compact 8 × 10 in footprint, $11,027 — the right pick for low-throughput or small-footprint requirements
- AP1096 IsoPure 96 — 96-sample throughput in deep-well plates, $49,376 — the right pick for high-throughput / batch workflows
Use the quote request to specify: voltage and plug type, kit chemistries the workflow uses (drives any custom protocol pre-loading recommendations), expected sample-volume range and throughput, and consumable-quantity inclusion in initial order (deep-well plates and tip combs run through quickly at full-capacity operation). Pre-installation training and protocol-validation support typically warranted at this price tier.
Warranty: 2 years. Extended above the typical Accuris standard, reflecting the institutional-procurement positioning of the IsoPure platform. Service, calibration validation, and consumable supply available through the Accuris service network.
IsoPure family selection guide:
- AP1016 Mini ($11K) — 16 samples / 50–1,000 µL / compact footprint / Bluetooth + PC app programming
- AP1024 ($51K) — 24 samples / 50–10,000 µL / 8-position carousel with 2 heating blocks (this product)
- AP1096 ($49K) — 96 samples in deep-well / 50–1,000 µL / high throughput
Pick the IsoPure that matches your throughput and per-sample volume; all three accept the same magnetic-bead kit chemistries.
