The IsoPure™ 96 is Accuris's high-throughput automated magnetic-bead purification platform — engineered to process up to 96 samples in deep-well plate format in a single hands-off run, with the same magnetic-bead chemistry compatibility as the rest of the IsoPure line. Where the AP1024 (IsoPure 24) handles 24 samples across a wider volume range (50 µL to 10 mL), the AP1096 trades volume range for plate-format throughput — 50 µL to 1,000 µL per sample, but 4× the sample count per cycle. A typical purification run completes in 10 to 60 minutes depending on the kit chemistry and protocol complexity. This is the spec for clinical-research, biobanking, and high-throughput-screening cores whose workflow is consistent-volume, plate-format, and throughput-bound.
Voltage options: This unit can be ordered with European voltage requirements (230V/50Hz). Contact us to order.
Key Specifications
| Capacity | Up to 96 samples per run |
| Sample volume range | 50 µL to 1,000 µL |
| Plate format | Deep-well plates (IsoPure deep-well plates fit the heating blocks for efficient heat transfer) |
| Carousel | 8-position with 2 heating blocks |
| Lysis & elution temperature range | Ambient +5 °C to 120 °C |
| Cooling | Cooling fans for ambient-temperature operation; programmable |
| Mixing | Programmable mixing time, speed, and amplitude per protocol step |
| Display | Color touchscreen (with included mouse for protocol creation) |
| Programming | On-instrument touchscreen, mouse, or PC connection |
| Run-time estimation | Built-in; displays per-step and total estimated time after protocol creation |
| Protocol duration | 10 to 60 minutes typical (depends on kit chemistry and protocol complexity) |
| Tip comb handling | Automated loading and unloading by designated plate positions in the script |
| Power input | Universal 120 to 240 VAC, 50/60 Hz |
Application Profile
High-throughput nucleic-acid extraction for clinical-research, diagnostic-development, and biobanking workflows that batch 48–96 samples per processing cycle. The 96-deep-well plate format aligns with downstream qPCR, NGS-library-prep, and microplate-format analytical workflows.
Magnetic bead transfer, washing, and elution — fully automated. After programming, the operator loads samples and reagents and walks away; the IsoPure 96 executes mixing, magnetic-bead transfer, washing, and elution steps without intervention. Hands-on time drops from a multi-hour manual protocol to ~10 minutes of setup plus walk-away processing.
Lysis and elution at controlled temperature. Two heating blocks on the carousel hold lysis and elution positions at programmable temperatures from ambient +5 °C to 120 °C. Heated lysis improves yield from difficult-to-lyse sample types (Gram-positive bacteria, plant tissue, fungal cells, archived FFPE tissue).
Multi-kit chemistry compatibility. Compatible with all popular magnetic-bead kits (Qiagen, Promega, NEB, Thermo, Zymo, third-party formulations) — the lab is not locked into a single proprietary reagent line.
Cross-contamination control. Bead Collection and Release sub-step is engineered for complete bead recovery from each sample mixture — important for maximizing yield and minimizing well-to-well carryover in a 96-format batch.
Automated tip-comb handling. Designated plate positions for tip comb loading and unloading mean the protocol script handles tip-comb placement automatically — no operator intervention to swap combs between protocol stages.
Design Architecture
Color touchscreen + mouse for protocol creation. Unlike the AP1016 (which programs via Android app or PC software), the AP1096 supports direct on-instrument programming via the touchscreen, with a USB mouse included for more complex protocol creation. The PC connection supports protocol export/import for centralized lab-wide protocol management.
Built-in run-time estimation. Once a protocol is programmed, the IsoPure 96 calculates and displays the estimated time per step plus total run time — useful for scheduling 96-sample runs around downstream PCR/NGS workflows.
Programmable mixing parameters per protocol step. Mixing time, speed, and amplitude can be tuned per step — gentle mixing for binding to avoid bead aggregation, vigorous mixing for washing to ensure complete carryover removal, custom mixing for elution.
Heating blocks at carousel positions for lysis and elution. IsoPure deep-well plates fit the blocks specifically — third-party plates may not contact the heating surface efficiently and may produce inconsistent temperature transfer across wells.
Cooling fans for ambient operation. Programmable to maintain ambient temperature when controlled-temperature steps aren't required, preventing chamber warm-up over multi-hour runs.
Bead Collection and Release sub-step — the protocol-step that captures all magnetic beads from the sample mixture into the comb, then releases them at the next position. Engineered for complete recovery to maximize yield in the 96-format throughput.
100-protocol on-instrument memory with PC export — multi-protocol cores can store the standard protocols for every kit chemistry the lab supports.
Frequently Asked Questions
How many samples can the AP1096 process per run? Up to 96 samples in deep-well plate format in a single hands-off run.
What is the sample volume range? 50 µL to 1,000 µL per sample.
How long does a purification run take? Typically 10 to 60 minutes, depending on the kit chemistry and protocol complexity.
Which magnetic-bead kits are compatible? All popular magnetic-bead kits — Qiagen, Promega, NEB, Thermo, Zymo, and third-party formulations — so the lab is not locked into one reagent line.
Should I pick the AP1096 or the AP1024? Pick the AP1096 for higher throughput at consistent volume (96 samples at ≤ 1 mL each). Pick the AP1024 when the workflow needs a wider volume range (up to 10 mL per sample) at 24 samples per cycle.
Ordering & Configuration
Standard configuration. The AP1096 ships with the instrument, 7-inch touchscreen and mouse for programming, magnetic assembly, universal 120–240 V power cord, operator's manual, and packaging materials.
Consumables (sold separately): Deep-well plates, tip combs, and magnetic-assembly accessories per workflow — confirm catalog SKUs and pack quantities at order.
Voltage variants:
- AP1096 — 115 V plug (this SKU)
Family alternatives:
- AP1016 IsoPure Mini — 16 samples / 50–1,000 µL / Bluetooth + PC app programming / 8 × 10 in footprint
- AP1024 IsoPure 24 — 24 samples / 50 µL to 10,000 µL — wider volume range, fewer per-cycle samples
Use the quote request to specify: voltage and plug type, expected throughput per week, kit chemistries used (drives any custom protocol pre-loading), deep-well plate and tip-comb consumable inventory inclusion, training, and lead time. Multi-day on-site protocol-validation support typically warranted at this institutional-procurement scale.
Warranty: Manufacturer's standard Accuris warranty applies.
AP1024 vs AP1096 selection: if your workflow needs wider sample-volume range (up to 10 mL per sample), pick the AP1024. If your workflow is higher throughput at consistent volume (96 samples per cycle at ≤ 1 mL each), pick the AP1096. Both have the same temperature-control and mixing capabilities; the differentiation is purely format and throughput.
