The Z446-750-A500 is the 500 mL conical bottle insert for the Hermle Z446-750-BUK round bucket on the Z446-750-AC 4-place swing-out rotor (Z446 / Z446-K chassis) — sold as a 2-pack. Each insert holds 1 × 500 mL conical bottle; the 4-bucket rotor configuration takes 2 packs (4 inserts) for full symmetric loading, delivering 4 × 500 mL bottles per cycle (2 L total) in swing-out geometry. The universe price-list label specifies Corning as the engineered bottle format pairing — the insert is dimensioned for Corning's 500 mL conical centrifuge bottle envelope (typical Corning 431123 conical bottle, with confirmed dimensional match recommended for other Corning 500 mL conical formats).
Bottle pairing note: The insert is a Hermle-engineered product; the Corning designation refers to the specific tube format the insert is dimensioned for, not to a third-party-branded SKU. The standard Hermle warranty applies to the insert. The Corning bottle is operator-supplied — purchase Corning's 500 mL conical centrifuge bottles separately to match the insert envelope.
Key Specifications
| SKU | Z446-750-A500 |
| Type | Bottle insert — 1 × 500 mL conical (Corning format) |
| Pack quantity | 2 inserts per SKU (full 4-bucket configuration takes 2 units = 4 inserts) |
| Per-insert capacity | 1 × 500 mL conical bottle (Corning format) |
| Per-cycle throughput (full configuration) | 4 × 500 mL = 2,000 mL total per cycle |
| Bottle format | 500 mL conical — engineered for Corning 500 mL conical centrifuge bottles (typical 97 mm OD, 148 mm length range) |
| Compatible bucket | Z446-750-BUK (round bucket; with Z446-750-LID PC-Screw cap for sealable mode) |
| Compatible rotor | Z446-750-AC (4-place swing-out rotor body) |
| Compatible chassis | Z446, Z446-K (refrigerated), and -E voltage variants |
| Cross-rotor dependency | Required co-purchase for the Z496-1000-A500C insert (Z496-K chassis 1,000 mL bucket family — see Z496-1000-A500C page for cross-rotor pairing context) |
| Max. operating speed (with insert + bottle) | Per Z446-750-AC spec — 4,000/4,500 rpm at 3,434–4,346 × g maximum |
| Max. radius | 19.2 cm |
| Temperature at max speed (refrigerated chassis) | 4 °C |
| Geometry | Swing-out (0–90°) — flat sediment surface |
| List price | $489 (2-pack) |
Compatibility & When to Order This SKU
Insert pairing — Z446-750-BUK round bucket only. Order this SKU when:
- Adding 500 mL Corning conical bottle workflow to an existing Z446 / Z446-K + Z446-750 install — order 2 units for full 4-bucket symmetric loading (2 L total per cycle).
- Cold-chain bulk-volume Corning bottle prep — when the workflow uses Corning's 500 mL conical centrifuge bottles for cell harvest, vaccine intermediate prep, or recombinant-protein bulk processing on the cold-chain swing-out chassis.
- Cross-rotor co-purchase for Z496-1000-A500C — when the Z496-1000-A500C insert is part of the Z496-K chassis configuration; the universe price-list label notes the Z496-1000-A500C "must be used with Z446-750-A500" — confirm cross-rotor dependency at order.
- Optional BSL-2 + workflow with the Z446-750-LID engaged.
- Replacement inserts if a current set is damaged or worn.
Why a Corning-Specific Insert SKU
The Z446-750-A500 is dimensioned for Corning's specific 500 mL conical centrifuge bottle geometry (typically Corning 431123 with confirmed dimensional match recommended for other 500 mL conical formats format). Corning's 500 mL conical bottles have a specific OD, length, and conical-tip envelope that differs from other commercial 500 mL conical bottle suppliers — the insert is dimensioned to match Corning's envelope precisely.
Bottle compatibility note: Third-party 500 mL conical bottles may fit the insert envelope if dimensions match Corning's specifications. Verify dimensions before ordering non-Corning bottles. The engineered Corning bottle pairing is the path with confirmed compatibility.
Author Confidence Note
This page is authored at medium confidence because:
- The Hermle brochure for Z446 includes the Z446-750-A500 SKU but does not document the specific Corning bottle part number or detailed envelope dimensions in the available brochure corpus
- The "Corning" pairing in the universe price-list label is workflow-target language, not full dimensional specification
- The cross-rotor dependency to Z496-1000-A500C ("must be used with Z446-750-A500" per universe label) suggests an unusual procurement coupling that may benefit from manufacturer clarification
Confirm at order: insert envelope dimensions (vs Corning's 500 mL conical bottle specifications), bottle source (Corning catalog), and cross-rotor dependency (whether the Z496-1000-A500C requires the Z446-750-A500 for joint workflow on a multi-chassis install).
Application Profile
Cold-chain bulk-volume cell harvest in Corning 500 mL conical — pelleting cells from 500 mL suspension culture batches at 4 × 500 mL parallel throughput per cycle on the cold-chain swing-out chassis with Corning's specific bottle geometry.
Vaccine-development bioprocess prep at 500 mL Corning conical — vaccine-development workflows that batch 500 mL Corning conical bottles for intermediate concentration steps with cold-chain integrity.
Recombinant-protein bulk prep workflows in Corning 500 mL conical — recombinant-protein expression and harvest in 500 mL Corning conical bottle format.
Cold-chain protein prep workflows in 500 mL conical — TCA, ammonium-sulfate, organic-precipitation in 500 mL working volume on the swing-out cold-chain platform with conical-tip pellet recovery.
Cross-rotor multi-chassis workflows — when the lab operates both a Z446-K chassis (this insert) and a Z496-K chassis with the Z496-1000-A500C insert, the cross-rotor pairing supports consolidated 500 mL Corning conical workflow across both chassis.
Cross-format Z446-K core facilities — labs running 500 mL Corning conical alongside other Z446-750 insert formats benefit from the cross-format insert family.
Ordering & Configuration
4-bucket symmetric loading. All 4 buckets must use matching A500 inserts for symmetric balance.
Bottle cap confirmation. All Corning bottles must be securely capped before spinning at 4,500 rpm — at 500 mL working volume and high RCF, cap integrity is critical.
Bottle volume balance. When the 4 bottles carry different sample volumes, pre-balance pairs by total mass before spinning.
Optional hermetic-seal engagement. When using the Z446-750-LID for biosafety workflows, confirm the lid is fully threaded onto each bucket before each spin.
Z446-750-A500 ships as 2 inserts. Bottles (Corning 500 mL conical) are operator-supplied from Corning's catalog.
Confirm at quote: bucket pairing (Z446-750-BUK in inventory; Z446-750-LID if biosafety required), chassis pairing (Z446 or Z446-K) and power configuration, bottle format (Corning 500 mL conical — verify Corning part number against insert envelope dimensions), cross-rotor dependency (whether the workflow also involves Z496-1000-A500C on a Z496-K chassis), pack count (2 packs for full 4-bucket configuration), and lead time.
Warranty: 5-Year Hermle warranty (3 years full + 2 years drivetrain) on the insert. Corning bottles follow Corning's manufacturer warranty.
Z446-750 bulk-volume bottle insert family (Z446-750-AC swing-out rotor):
- Z446-750-A500 (this product) — 500 mL Corning conical (4/cycle, 2 L total)
- Z446-750-A250 / A250F — 250 mL bottle variants
- Z446-750-A225 — 175/225 mL conical (Hermle C0175 / C0225)
The A500 is the largest bottle insert in the Z446-750 swing-out family — pick when the workflow uses Corning's 500 mL conical bottles for bulk-volume processing.
