The Z496-1000-A500C is the rectangular holder for the Z446-750-A500 conical insert. It mounts on the Hermle Z496-1000-RBUK rectangular bucket on the Z496-K chassis 4-place swing-out rotor, sold as a 2-pack. Per Fred 2026-05-05 (FQ-009 resolved), this is a mechanical chassis-pairing dependency: the Z496-1000-A500C does NOT include the A500 insert. Customers must own (or order) the Z446-750-A500 separately for this holder to function. Each holder accepts 1 × Z446-750-A500 (which holds 1 × 500 mL Corning conical bottle); the 4-bucket Z496-K configuration takes 2 packs of A500C + 2 packs of A500 (4 holders + 4 inserts) for full symmetric loading, delivering 4 × 500 mL Corning conical bottles per cycle (2 L total).
REQUIRES Z446-750-A500, DOES NOT FUNCTION STANDALONE
The Z496-1000-A500C is a rectangular holder for the Z446-750-A500 conical insert. It does NOT include the A500 insert itself. Customers must own (or order) the Z446-750-A500 separately for the Z496-1000-A500C to function. Do NOT order Z496-1000-A500C as a standalone 500 mL conical insert.
Resolved 2026-05-05 by Fred (Hermle): mechanical chassis-pairing dependency confirmed. Same pattern as DP0150-10/-12 → DP0650 and R2020-PCR/-RP → R2024 chassis-pairing safeguards.
Key Specifications
| SKU | Z496-1000-A500C |
| Type | Rectangular holder for Z446-750-A500 conical insert (mechanical chassis-pairing dependency; REQUIRES A500) |
| Pack quantity | 2 holders per SKU (full 4-bucket configuration takes 2 units = 4 holders, plus 2 packs of Z446-750-A500 = 4 inserts) |
| Per-holder capacity | 1 × Z446-750-A500 insert (which holds 1 × 500 mL Corning conical bottle) |
| Per-cycle throughput (full configuration) | 4 × 500 mL = 2,000 mL total per cycle |
| Bottle format | 500 mL Corning conical centrifuge bottle (typical Corning 431123; see Z446-750-A500 page) |
| 🚨 Required co-purchase (mechanical chassis-pairing) | Z446-750-A500 insert: REQUIRED (per Fred 2026-05-05, FQ-009: A500C is a holder, not an insert) |
| Compatible bucket | Z496-1000-RBUK (rectangular bucket on Z496-1000-AC swing-out rotor) |
| Compatible rotor | Z496-1000-AC (4-place swing-out rotor body without buckets) |
| Compatible chassis (assembled) | Z496-K (Floor-Standing, 230 V) and Z496-K-UC (Underbench, 230 V) |
| Max. operating speed (with insert + bottle) | Per Z496-1000-RBUK spec (4,200 rpm at 3,964 × g maximum) |
| Max. radius | 20.1 cm |
| Temperature at max speed (Z496-K refrigerated) | 7 °C |
| Geometry | Swing-out (0–90°): flat sediment surface |
| List price | $606 (2-pack) |
Compatibility & When to Order This SKU
Insert pairing: Z496-1000-RBUK rectangular bucket only. Order this SKU when:
- Adding 500 mL Corning conical bottle workflow to a Z496-K + Z496-1000-RBUK install. Order 2 units for full 4-bucket symmetric loading (2 L total per cycle).
- Cross-chassis Corning 500 mL workflow consolidation: when the lab operates both a Z446-K and a Z496-K chassis with shared Corning 500 mL bottle inventory and needs the cross-chassis insert pairing.
- High-throughput cold-chain Corning 500 mL bulk prep on Z496-K: when the Z496-K's swing-out platform delivers the workflow's RCF and cold-chain requirements at 2 L per cycle.
- Replacement inserts if a current set is damaged or worn (confirm cross-rotor dependency at re-order).
Application Profile
Cold-chain Corning 500 mL conical bottle prep on Z496-K: vaccine-development, recombinant-protein, and bioprocess workflows that batch 4 × 500 mL Corning conical bottles per cycle on the Z496-K cold-chain swing-out chassis.
Cross-chassis Corning 500 mL workflow consolidation: labs operating both Z446-K and Z496-K chassis with shared Corning bottle inventory benefit from cross-chassis insert pairing for workflow flexibility.
Bulk-volume cell harvest in Corning 500 mL conical: pelleting cells from 500 mL suspension culture batches at institutional throughput.
Vaccine-development bioprocess prep at 500 mL: vaccine-development workflows that batch Corning 500 mL conical bottles for intermediate concentration steps with cold-chain integrity.
Cross-format Z496-K core facilities: labs running 500 mL Corning conical alongside other Z496-1000-RBUK insert formats (A500, A250, A225, A50, A10) benefit from the cross-format insert family.
Ordering & Configuration
4-bucket symmetric loading. All 4 buckets must use matching A500C holders (each loaded with a Z446-750-A500 insert) for symmetric balance.
Bottle cap confirmation. All Corning bottles must be securely capped before spinning at 4,200 rpm.
Z496-1000-A500C ships as 2 holders. The Z446-750-A500 inserts (required for function) and Corning 500 mL conical bottles are sold separately.
Confirm at quote: bucket pairing (Z496-1000-RBUK in inventory), chassis pairing (Z496-K or Z496-K-UC), A500 insert co-procurement (Z446-750-A500 (REQUIRED, mechanical chassis-pairing dependency per Fred 2026-05-05), bottle format (Corning 500 mL conical) verify part number and dimensions), pack count (2 packs A500C holders + 2 packs A500 inserts for full 4-bucket configuration), and lead time.
Warranty: 5-Year Hermle warranty (3 years full + 2 years drivetrain) on the inserts. Corning bottles follow Corning's manufacturer warranty.
Z496-1000-RBUK insert family: bottle and tube formats (Z496-K chassis):
- Z496-1000-A500C (this product): Rectangular holder for Z446-750-A500 (Corning 500 mL conical workflow; A500 insert REQUIRED)
- Z496-1000-A500: 500 mL bottle (Hermle C1500)
- Z496-1000-A250: 2 × 250 mL bottle (Hermle C1250)
- Z496-1000-A225: 225 mL conical (Hermle C0225)
- Z496-1000-A100: 100 mL bottle
- Z496-1000-A85: 85 mL bottle
- Z496-1000-A50: 8 × 50 mL conical
- Z496-1000-A10: 38 × 10 mL Vacutainer (152/cycle, highest 10 mL throughput in catalog)
The A500C is the rectangular holder that mounts the Z446-750-A500 insert on the Z496-1000-RBUK bucket, mechanical chassis-pairing dependency confirmed by Fred 2026-05-05.
