Cellpuri Cell Separation System, Centrifuge-Free Microfluidic Cell Enrichment

The Yamato CCP-FP is the Cellpuri cell separation system, an innovative, disposable microfluidic chip that concentrates and enriches cells without centrifugation. Using proprietary Filterless Filter (FLF) technology, it separates cells by size within microchannels as the suspension flows through, filtering out waste medium and collecting enriched cells at the outlet. It achieves over 20-fold enrichment in about 2 minutes with roughly 95% cell recovery, and because the method is shear-stress-free, it protects fragile samples and reduces clumping. The chip operates within a standard clean bench.

Key Specifications

Application Profile

Centrifugation is the default way to concentrate cells, but it is also rough on them, the pelleting forces impose shear and mechanical stress that damage fragile cell types, trigger clumping, and lower viability. For delicate primary cells, stem cells, immune cells, and other sensitive samples, that damage is a real experimental cost. Cellpuri replaces the centrifuge with microfluidics: cell suspension flows through channels where the Filterless Filter geometry uses a rheological (flow-based) phenomenon to separate cells by size, routing waste medium away and concentrating the target cells at the outlet, with no membrane to clog and no pelleting force.

The performance figures are the selling point: >20× enrichment in ~2 minutes at ~95% recovery, gently enough to maintain high viability and reduce aggregation. That makes Cellpuri well suited to preparing sensitive cells for downstream single-cell workflows, imaging, and analysis, where a centrifuge step would compromise the very cells you want to study. Because each chip is disposable and runs on a clean bench, it also removes cross-contamination risk between samples.

Frequently Asked Questions

What does the Cellpuri chip do? It concentrates and enriches cells without centrifugation, using microfluidic Filterless Filter (FLF) technology to separate cells by size and collect them at the outlet.

How much enrichment and recovery does it achieve? Over 20-fold enrichment in about 2 minutes, with roughly 95% cell recovery at high viability.

Why avoid centrifugation? Centrifugal pelleting imposes shear and mechanical stress that damages fragile cells and causes clumping. Cellpuri's shear-stress-free flow method is gentle, protecting viability and reducing aggregation.

Is it a single-use device? Yes. Cellpuri is a disposable chip, which also eliminates cross-contamination between samples.

Where is it operated? Within a standard clean bench, no dedicated instrument or centrifuge is required to run it.

What samples benefit most? Delicate and shear-sensitive cells (primary cells, stem cells, immune cells) being prepared for single-cell workflows, imaging, or analysis.

Ordering & Configuration

Confirm at quote: chip quantities for your throughput, sample types and input volumes, and integration with your downstream single-cell or imaging workflow.

Warranty: Per Yamato standard capital-equipment terms. Confirm coverage at quote.

Add to a quote to lock quantities and lead time.

Positioning: the CCP-FP is chosen when you need to concentrate cells gently (especially fragile samples that a centrifuge would damage) delivering >20× enrichment in ~2 minutes at ~95% recovery on a disposable, clean-bench chip. It pairs naturally with downstream single-cell and live-cell imaging workflows where cell viability is the whole point.