The Z216-24SC is the 24-position spin column kit rotor for the Hermle Z216 series chassis (Z216-M and Z216-MK) — engineered for silica- and membrane-based spin column extraction kits (Qiagen, Zymo Research, Promega, Bio-Rad, NEB and equivalent commercial kit chemistries). Spin columns combine a column body (filter membrane on a frit) with a 1.5 / 2.0 mL collection tube; the column-plus-tube assembly is taller than a standard microtube alone — the SC rotor geometry accommodates this taller stack with the correct hub depth and spindle clearance on the Z216 series chassis.
Universe class flag: The universe price list classifies this SKU as consumable, but the SKU is functionally a rotor (sister to the class=accessory Z207-24SC and Z287-24SC rotor SKUs at similar pricing on Z207-M and Z287-A chassis respectively). Flagging for post-launch class correction to accessory.
Key Specifications
| SKU | Z216-24SC |
| Type | Fixed-angle spin column rotor — 24 position |
| Capacity | 24 × 1.5 / 2.0 mL spin column kit assemblies |
| Compatible chassis | Z216 series — Z216-M, Z216-MK (refrigerated), and -E voltage variants |
| Angle | 45° |
| Lid | Hermetically sealed |
| Sample compatibility | Standard 1.5 / 2.0 mL spin column + collection tube assemblies — silica, anion-exchange, size-exclusion, affinity-bead column formats |
| Adapter compatibility | C1008-A5-6 (0.5 mL); C1008-A2-6 (0.4/0.2 mL PCR) — for downstream microtube use |
Spin Column Kit Compatibility
Standard silica and membrane spin columns from major commercial extraction kits seat into the SC rotor positions:
- DNA extraction kits — genomic DNA, plasmid mini-prep, gel extraction, PCR cleanup
- RNA extraction kits — total RNA, mRNA, miRNA isolation
- Protein column kits — affinity-tag purification at micro-prep scale, antibody cleanup, peptide enrichment
- Methylation, ChIP, ATAC-seq column kits — epigenetic-prep workflows
The rotor geometry accepts standard column body dimensions (typical column OD ~9–11 mm; standard collection tube format 1.5 / 2.0 mL). Confirm at order if the workflow uses non-standard column dimensions (some specialty kits use proprietary geometries).
Why "SC" Geometry on the Z216 Series
Standard microtube rotors on the Z216 series (Z216-2420, Z216-2420H, Z216-COMBI-Rotor) are dimensioned for the microtube alone. Spin column assemblies stack the column body on top of the collection tube, increasing total height — the SC rotor's hub depth and spindle clearance accommodate this stack while maintaining the 45° angle and balanced rotation. Running spin columns in a non-SC microtube rotor is a fit problem (column may not seat fully) and a balance problem (irregular column-body weight distribution at the high-RCF range the Z216 series delivers).
The hermetically sealed lid supports BSL-2 + extraction workflows where aerosol containment matters (extraction protocols handling potentially infectious patient samples for diagnostic or research workflows).
Application Profile
Routine DNA / RNA extraction at clinical-research and core-facility scale on Z216 series — the dominant use case. Most commercial extraction kits center on the silica spin-column workflow; the Z216 series + Z216-24SC combination delivers clean prep for downstream PCR, qPCR, sequencing, and microarray assays at the high-speed Z216 chassis range.
24-sample batches per cycle — matches the typical 96-well plate quadrant batch size (24 = 1/4 of a 96-well plate) common in extraction prep workflows.
Pre-PCR and pre-qPCR sample prep — extract DNA / RNA into the SC rotor, then transfer eluate to PCR plate or strip for amplification.
Gel and PCR cleanup — post-amplification or post-restriction-digest cleanup using gel-extraction or PCR-cleanup column kits.
Plasmid mini-prep — bacterial-culture-derived plasmid prep for cloning workflows; the SC rotor handles the typical 24-clone screening batch in a single cycle.
Cold-chain extraction workflows on Z216-MK — refrigerated extraction prep when the workflow requires cold-chain integrity through the spin column elution step.
BSL-2 + extraction workflows — when extraction protocols handle potentially infectious patient samples requiring aerosol containment via the hermetic lid.
Ordering & Configuration
24-position symmetric loading. Pair opposites by mass; spin column assemblies have variable mass during the workflow — column with binding buffer is heavier than column with eluate — so re-balance pairs at each spin step in a multi-step extraction protocol.
Hermetic-seal engagement. The hermetically sealed lid must be fully engaged before each spin to maintain the seal at the rotor's high RCF.
Selectable accel/decel. Z216 chassis profiles apply; the unbraked extended-decel profile preserves loose silica-bound material during the elution step.
Z216-24SC ships as the rotor body + lid. Spin column kits, reagents, and adapters for downstream microtube use (C1008-A5-6, C1008-A2-6) are sold separately or supplied per the user's chosen kit.
Confirm at quote: chassis pairing (Z216-M or Z216-MK), kit chemistry intended (most major kits compatible — confirm if using non-standard column geometry), workflow biosafety driver (hermetic lid supports BSL-2 + workflows), and lead time.
Warranty: 5-Year Hermle warranty (3 years full + 2 years drivetrain) on the rotor body and lid.
Spin column rotor selection across Hermle chassis families:
- Z216-24SC (this product) — Z216 series chassis (high-speed microcentrifuge platform with hermetic-seal lid)
- Z207-24SC — Z207-M chassis (compact microcentrifuge)
- Z287-24SC — Z287-A chassis (compact universal)
Pick the Z216-24SC when the lab's extraction workflow runs on the Z216 series chassis and needs the hermetic-seal lid for biosafety containment.
